Antidepressant use and risk of adverse outcomes in people aged 20-64 years: cohort study using a primary care database.
Carol A C CouplandTrevor HillRichard MorrissMichael MooreAntony ArthurJulia Hippisley-CoxPublished in: BMC medicine (2018)
Selective serotonin reuptake inhibitors had higher rates of fracture than tricyclic and related antidepressants but lower mortality and adverse drug reaction rates than the other antidepressant drug classes. The association between mirtazapine and increased mortality merits further investigation. These risks should be carefully considered and balanced against potential benefits for individual patients when the decision to prescribe an antidepressant is made.
Keyphrases
- adverse drug
- major depressive disorder
- primary care
- end stage renal disease
- cardiovascular events
- ejection fraction
- newly diagnosed
- bipolar disorder
- chronic kidney disease
- electronic health record
- prognostic factors
- human health
- risk factors
- emergency department
- drug induced
- peritoneal dialysis
- type diabetes
- risk assessment
- coronary artery disease
- patient reported outcomes
- general practice
- climate change
- hip fracture
- electron transfer