Whole-exome sequencing identifies novel pathogenic variants across the ATP7B gene and some modifiers of Wilson's disease phenotype.
Anna KluskaMaria KuleckaTomasz LitwinKarolina DziezycAneta BalabasMagdalena PiatkowskaAgnieszka PaziewskaMichalina DabrowskaMichal MikulaDiana KaminskaAnna WiernickaPiotr SochaAnna CzlonkowskaJerzy OstrowskiPublished in: Liver international : official journal of the International Association for the Study of the Liver (2018)
In a Polish population, genetic screening for WD may help genotype for four variants (p.His1069Gln, p.Gln1351Ter, p.Trp779Ter and c.3402delC), with direct sequencing of all ATP7B amplicons as a second diagnostic step. We also identified some allelic variants that may modify a WD phenotype.