The Autoantigenic Proinsulin B-Chain Peptide B11-23 Synergises with the 70 kDa Heat Shock Protein DnaK in Macrophage Stimulation.

Elias BlasiusElke GüldenHubert KolbChristiane HabichVolker Burkart

Published in: Journal of diabetes research (2018)

The macrophage-stimulating potential of Hsp70 family proteins when combined with the proinsulin B-chain peptide B11-23 may contribute to the immunodominance of this peptide in the development of beta cell-directed autoimmunity in type 1 diabetes.

Keyphrases

heat shock protein
type diabetes
heat shock
adipose tissue
single cell
cardiovascular disease
cell therapy
risk assessment
heat stress
bone marrow
climate change