Pharmacokinetics of vaginally applied integrase inhibitors in macaques.
Kenji NishiuraSunita SharmaMara SterlingNatalia MakarovaAmy MartinChuong DinhJames MitchellJ Gerardo García-LermaWalid HeneineCharles W DobardPublished in: The Journal of antimicrobial chemotherapy (2021)
To the best of our knowledge, this study provides the first data on INSTI levels in vaginal tissues associated with in vivo protection and demonstrates rectal drug distribution of INSTIs after vaginal dosing. These findings may inform dose selection for topical products with INSTIs for HIV prevention.