Diffusion-weighted imaging lesion growth occurs despite recanalization in acute ischemic stroke: Implications for future treatment trials.
Rani G SahChristopher D d'EsterreMichael D HillMoiz HafeezSana TariqNils D ForkertRichard FrayneAndrew M DemchukMayank GoyalPhilip A BarberPublished in: International journal of stroke : official journal of the International Stroke Society (2018)
Despite best efforts to recanalize the ischemic brain, early diffusion-weighted imaging lesion growth still occurs. Treatment trials in stroke should consider early diffusion-weighted imaging lesion growth as a surrogate outcome measure to significantly reduce sample sizes.