Aberrant characteristics of peripheral blood innate lymphoid cells in COPD, independent of smoking history.
Cathelijne M van ZelstJohannes C C M In 't VeenLisette KrabbendamGeertje Maria de BoerMarjolein J W de BruijnMenno van NimwegenEsmee K van der PloegDenise van UdenRalph StadhoudersGerdien A Tramper-StandersRudi W HendriksGerrit Johannes BraunstahlPublished in: ERJ open research (2024)
Our in-depth characterisation of ILC1 and ILC2 populations in peripheral blood revealed significant differences in their phenotypes between COPD and asthma patients and smoking or non-smoking controls. These findings suggest a role for both ILC subsets in COPD disease pathology, independent of smoking history, and may have implications for patient stratification and therapy development.