Plasma and CSF biomarkers of aging and cognitive decline in Caribbean vervets.

Curran VarmaEva LuoGustaf BostromPraveen BathiniDaniela BerdnikTony Wyss-CorayTingting ZhaoXianjun DongFrank R ErvinAmy BeierschmittRoberta M PalmourCynthia A Lemere

Published in: Alzheimer's & dementia : the journal of the Alzheimer's Association (2024)

We found changes in immune and metabolic plasma biomarkers associated with age and cognition. Cerebrospinal fluid (CSF) biomarkers revealed changes in cell signaling indicative of adaptative processes. TNFRSF19 (TROY) and Artemin co-localize with Alzheimer's disease pathology. Vervets are a relevant model for translational studies of early-stage Alzheimer's disease.

Keyphrases

cognitive decline
mild cognitive impairment
cerebrospinal fluid
early stage
single cell
stem cells
cell therapy
lymph node
squamous cell carcinoma
mesenchymal stem cells
sentinel lymph node
neoadjuvant chemotherapy