Impact of reproductive aging on the vaginal microbiome and soluble immune mediators in women living with and at-risk for HIV infection.
Kerry MurphyMarla J KellerKathryn AnastosShada SinclairJ Cooper DevlinQiuhu ShiDonald R HooverBrian StarkmanJamie McGillickCaroline MullisHoward MinkoffMaria Gloria Dominguez-BelloBetsy C HeroldPublished in: PloS one (2019)
HIV+ postmenopausal compared to premenopausal participants have less CVL E. coli bactericidal activity, reflecting a reduction in Lactobacilli and a greater proportion of Gardnerella and A. vaginae, and more HSV-2 inhibitory activity, reflecting increased mucosal inflammation. The effect of menopause on mucosal immunity was greater in HIV+ participants, suggesting a synergistic impact. Promotion of a lactobacillus dominant vaginal microbiome and reduced mucosal inflammation may improve vaginal health and reduce risk for shedding of HIV and potential for HIV transmission in HIV+ menopausal women.
Keyphrases
- antiretroviral therapy
- hiv positive
- hiv infected
- hiv testing
- human immunodeficiency virus
- hiv aids
- hepatitis c virus
- men who have sex with men
- oxidative stress
- polycystic ovary syndrome
- south africa
- escherichia coli
- healthcare
- adipose tissue
- mental health
- breast cancer risk
- pregnant women
- risk assessment
- insulin resistance
- ulcerative colitis
- skeletal muscle
- pregnancy outcomes
- cancer therapy