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Use of the von Willebrand factor concentrate with low factor VIII content to manage patients with inherited von Willebrand disease requiring surgical or secondary long-term prophylaxis: An expert opinion paper from an Italian panel.

Giancarlo CastamanAlessandra BorchielliniAntonio CoppolaDorina CultreraRenato MarinoAugusto B FedericiAnna Chiara GiuffridaEmanuela MarchesiniAngelo Claudio MolinariSiboni Simona MariaEzio Zanon
Published in: European journal of haematology (2022)
Considering that patients affected by VWD have an intact ability to synthesize FVIII, in order to avoid excessive levels of FVIII, a highly purified plasma VWF concentrate with low FVIII content could be particularly useful in those patients and clinical circumstances at high thrombotic risk as well as for long-term prophylaxis. When deciding the optimal therapeutic strategy, physicians should take into account both the patient's history and the differences among available concentrates according to the clinical situations requiring treatment.
Keyphrases
  • end stage renal disease
  • ejection fraction
  • newly diagnosed
  • chronic kidney disease
  • peritoneal dialysis
  • primary care
  • case report
  • weight loss
  • smoking cessation