A SUMOylation wave to anchor the genome.

Published in: The Journal of cell biology (2021)

Chromatin tethers to the nuclear envelope are lost during mitosis to facilitate chromosome segregation. How these connections are reestablished to ensure functional genome organization in interphase is unclear. Ptak et al. (2021. J. Cell Biol.https://doi.org/10.1083/jcb.202103036) identify a phosphorylation and SUMOylation-dependent cascade that links chromatin to the nuclear membrane during late mitosis.

Keyphrases

genome wide
dna damage
gene expression
transcription factor
copy number
dna methylation
single cell
cell therapy
stem cells
oxidative stress