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Mefloquine enhances the efficacy of anti-PD-1 immunotherapy via IFN-γ-STAT1-IRF1-LPCAT3-induced ferroptosis in tumors.

Qian TaoNian LiuJie WuJing ChenXiang ChenCong Peng
Published in: Journal for immunotherapy of cancer (2024)
In conclusion, our study demonstrated a novel mechanism by which LPCAT3 is regulated, and demonstrated that Mef is a highly promising new target that can be utilized to enhance the efficacy of anti-PD-1 immunotherapy.
Keyphrases
  • dendritic cells
  • cell death
  • immune response
  • high glucose
  • cell proliferation
  • diabetic rats
  • transcription factor
  • drug induced