Multivalent non-covalent interfacing and cross-linking of supramolecular tubes.

Natural supramolecular filaments have the ability to crosslink with each other and to interface with the cellular membrane via biomolecular non-covalent interactions. This behavior allows them to form complex networks within as well as outside the cell, i.e., the cytoskeleton and the extracellular matrix, respectively. The potential of artificial supramolecular polymers to interact through specific non-covalent interactions has so far only seen limited exploration due to the dynamic nature of supramolecular interactions. Here, we demonstrate a system of synthetic supramolecular tubes that crosslink forming supramolecular networks, and at the same time bind to biomimetic surfaces by the aid of non-covalent streptavidin-biotin linkages. The architecture of the networks can be engineered by controlling the density of the biotin moiety at the exterior of the tubes as well as by the concentration of the streptavidin. The presented strategy provides a pathway for designing adjustable artificial supramolecular superstructures, which can potentially yield more complex biomimetic adaptive materials. This article is protected by copyright. All rights reserved.