Mice Selected for Acute Inflammation Present Altered Immune Response during Pristane-Induced Arthritis Progression.
Mara A CorreaAndrea BorregoJosé Ricardo JensenWafa Hanna Koury CabreraMichele BarrosIana S S KatzTatiane CanhameroMonica Spadafora-FerreiraJussara G FernandesNancy StarobinasOrlando Garcia RibeiroOlga Célia Martinez IbañezMarcelo De FrancoPublished in: BioMed research international (2018)
Mouse lines selected for maximal (AIRmax) or minimal acute inflammatory reaction (AIRmin) were used to characterize the immune response and the influence of genetic background during pristane-induced arthritis (PIA). Susceptible AIRmax mice demonstrated exacerbated cellular profiles during PIA, with intense infiltration of lymphocytes, as well as monocytes/macrophages and neutrophils, producing higher levels of IL-1β, IFN-γ, TNF-α, IL-10, total IgG3, and chemokines. Resistant AIRmin mice controlled cell activation more efficiently than the AIRmax during arthritis progression. The weight alterations of the spleen and thymus in the course of PIA were observed. Our data suggest that selected AIRmax cellular and genetic immune mechanisms contribute to cartilage damage and arthritis severity, evidencing many targets for therapeutic actions.
Keyphrases
- immune response
- rheumatoid arthritis
- drug induced
- oxidative stress
- high fat diet induced
- liver failure
- dendritic cells
- diabetic rats
- high glucose
- respiratory failure
- genome wide
- peripheral blood
- body mass index
- physical activity
- single cell
- wild type
- toll like receptor
- endothelial cells
- hepatitis b virus
- cell therapy
- dna methylation
- intensive care unit
- electronic health record
- gene expression
- weight gain
- metabolic syndrome
- inflammatory response
- big data
- machine learning
- deep learning
- body composition
- mechanical ventilation