Catalytic aminomethylative etherification of N -allenamides with N , O -acetals enabled by Lewis/Brønsted acid catalysis.

A novel copper-catalyzed aminomethylative etherification of N -allenamides/alkoxyallenes with N , O -acetals has been realized under mild reaction conditions, in which every single atom of N , O -acetals is incorporated into the newly formed molecules. Furthermore, in the presence of a chiral phosphoric acid, the asymmetric aminomethylative etherification of N -allenamides has been accomplished using N , O -acetals as bifunctionalization reagents.