Chemokine CXCL1 in serum mediates the antinociceptive effect of manual acupuncture at ST36.

Shou-Hai HongSha-Sha DingYuan XuKuo ZhangXue ZhaoYang-Yang LiuLi-Hua XuanYong-Ming GuoYi Guo

Published in: Acupuncture in medicine : journal of the British Medical Acupuncture Society (2021)

This study indicates MA at ST36 had an analgesic effect on inflammatory pain and found a novel function of CXCL1. Increased serum CXCL1 had an antinociceptive effect on inflammatory pain induced by CFA. CXCL1 in serum appeared to be a key molecule involved in the peripheral mechanism of MA-induced antinociception. The analgesic effect of MA or recombinant CXCL1 on inflammatory pain might be mediated through a peripheral opioid pathway, which needs further investigation.

Keyphrases

chronic pain
neuropathic pain
pain management
anti inflammatory
oxidative stress
spinal cord
spinal cord injury
high glucose
chemotherapy induced
postoperative pain
drug induced
cell free