Glycycoumarin protects mice against acetaminophen-induced liver injury predominantly via activating sustained autophagy.

Mingzhu YanLinhu YeShutao YinXiaotong LuXiaoyi LiuShangyun LuJinling CuiLihong FanNeil KaplowitzHongbo Hu

Published in: British journal of pharmacology (2018)

Collectively, our results indicate that GCM alleviated acetaminophen-induced oxidative stress through activating autophagy, thereby protecting against AILI. Our findings suggest that GCM has potential as a novel therapeutic agent for treating AILI.

Keyphrases

signaling pathway
cell death
endoplasmic reticulum stress
liver injury
oxidative stress
hydrogen peroxide
high fat diet induced
drug induced
nitric oxide
risk assessment
adipose tissue