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Stretch- and carbachol-induced ATP release from bladder wall preparations of young and aged mice.

Nobuyuki NishikawaBasu ChakrabartyDarryl KitneyRita JabrAnthony J KanaiChristopher Henry Fry
Published in: Neurourology and urodynamics (2020)
With young mice, stretch, or muscarinic agonists potently induce bladder wall ATP release. Stretch-dependent release is proportional to bladder wall stiffness, independent of the extent of stretch. With aged mice dependence of stretch-activated ATP release with stiffness was lost. The huge variability of release suggests that aged mice do not form a homogenous cohort and may underlie the heterogeneity in bladder filling sensations.
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