[Association of polymorphic markers of chemokine genes, their receptors, and CD14 gene with coronary atherosclerosis].
T R NasibullinL F YagafarovaI R YagafarovYa R TimashevaV V ErdmanI A TuktarovaO E MustafinaPublished in: Genetika (2018)
Atherosclerosis represents an inflammatory response to the disturbance of the endothelial layer in the arterial bloodstream. In the present study, an analysis of associations of polymorphic markers for the genes controlling synthesis of proteins involved in atherosclerosis pathogenesis in coronary atherosclerosis (CA) patients (217 subjects) and in a control group (250 subjects) was conducted. The following genes were examined: rs991804 (CCL2 gene), rs1126579 (CXCR2 gene), rs4074 (CXCL1 gene), rs4073 (CXCL8 gene), rs333 (CCR5 gene), rs2471859 (CXCR4 gene), rs1801157 (CXCL12 gene), and rs2569190 (CD14 gene). Using the Monte Carlo and Markov chain (APSampler) method, allele/genotype combinations associated with both low and high CA risk were revealed. The most important findings included the following: CXCR4*T/T + CCL2*C + CCR5*I/I (P perm = 1 × 10–6, OR = 0.44, 95% CI 0.3–0.63), CXCR2*C + CD14*C + CXCL12*G + CCL2*C + CCR5*D (P perm = 4 × 10–6, OR = 5.78, 95% CI 2.34–14.28), CD14*C + CCL2*C/C + CCR5*D (P perm = 6.3 × 10–6, OR = 5.81, 95% CI 2.17–15.56), CXCL8*A + CXCR2*C + CD14*T + CXCR4*C (P perm = 0.01, OR = 3.21, 95% CI 1.63–6.31).
Keyphrases
- genome wide
- genome wide identification
- copy number
- cardiovascular disease
- coronary artery
- genome wide analysis
- gene expression
- dendritic cells
- transcription factor
- immune response
- escherichia coli
- aortic valve
- oxidative stress
- atrial fibrillation
- liver injury
- multidrug resistant
- prognostic factors
- gram negative
- drug induced