A thiosemicarbazone derivative induces triple negative breast cancer cell apoptosis: possible role of miRNA-125a-5p and miRNA-181a-5p.

Rania El MajzoubMohammad Fayyad-KazanAssaad Nasr El DineRawan MakkiEva HamadeRené GréeAli HachemRabih TalhoukHussein Fayyad-KazanBassam Badran

Published in: Genes & genomics (2019)

Collectively, our results demonstrate an anti-TNBC activity of Cisplatin + thiosemicarbazone compound 4 combination mediated via induction of apoptosis.

Keyphrases

oxidative stress
endoplasmic reticulum stress
cell proliferation
cell cycle arrest
cell death
pi k akt