A Decision Support Tool for Allogeneic Hematopoietic Stem Cell Transplantation for Children With Sickle Cell Disease: Acceptability and Usability Study.
Anirudh VeludhandiDiana RossCynthia B SinhaCourtney E McCrackenNitya BakshiLakshmanan KrishnamurtiPublished in: JMIR formative research (2021)
We report the development, acceptability, and usability of a prototype decision support tool app to provide individualized risk and survival estimates to patients interested in HCT in a patient consultation setting. We propose to finalize the tool by validating predictive analytics using a large data set of patients with SCD who have undergone HCT. Such a tool may be useful in promoting physician-patient collaboration in making shared decisions regarding HCT for SCD. Further incorporation of patient-specific measures, including the HCT comorbidity index and the quality of life after transplant, may improve the applicability of the decision support tool in a health care setting.
Keyphrases
- allogeneic hematopoietic stem cell transplantation
- healthcare
- electronic health record
- cell cycle arrest
- emergency department
- case report
- acute lymphoblastic leukemia
- end stage renal disease
- newly diagnosed
- big data
- health information
- acute myeloid leukemia
- ejection fraction
- young adults
- cell death
- prognostic factors
- patient reported outcomes
- pi k akt