Mitochondrial Stress-Mediated Targeting of Quiescent Cancer Stem Cells in Oral Squamous Cell Carcinoma.
Tajindra Singh SalujaVijay KumarMonika AgrawalAbhilasha TripathiRajesh Kumar MeherKamini SrivastavaAnurag GuptaAnjana SinghArun ChaturvediSatyendra Kumar SinghPublished in: Cancer management and research (2020)
We report marker-based identification of CSC subpopulations and synergy of Dyrk1b inhibitor with topoisomerase II and HDAC inhibitors in primary OSCC. The results provide a new therapeutic strategy to minimize quiescence and target oral CSCs simultaneously.