Impact of Caffeine on Ethanol-Induced Stimulation and Sensitization: Changes in ERK and DARPP-32 Phosphorylation in Nucleus Accumbens.

Simona Porru Laura Lopez-Cruz Carla Carratalá-Ros John D Salamone Elio Acquas Mercè Correa

Published in: Alcoholism, clinical and experimental research (2021)

The present results demonstrated that, after the first administration, caffeine potentiated the stimulating actions of ethanol, but did not counteract its suppressant or ataxic effects. Moreover, our results show that caffeine has less activating effects in ethanol-sensitized animals.

Keyphrases

signaling pathway
oxidative stress
pi k akt
drug induced
protein kinase