Interhemispheric Pediatric Meningioma, YAP1 Fusion-Positive.

Meningiomas are uncommon in children and usually arise in the context of tumor-predisposing syndromes. Recently, YAP1 -fusions have been identified for the first time as potential NF2 -independent oncogenic drivers in the development of meningiomas in pediatric patients. We report a case of a YAP1 -fusion-positive atypical meningioma in a young child and compare it with the previous ones reported. Extending the clinico-pathological features of YAP1 -fused meningiomas, we suggest additional clues for diagnosis and emphasize the urgent need for an integrated multilayered diagnostic approach, combining data from histological and molecular analyses, neuroradiology, and clinical findings.