Clinical manifestation for immunoglobulin A deficiency: a systematic review and meta-analysis.

Ahmad VosughimotlaghSeyed Erfan RasouliHosein RafiemaneshMolood SafariradNiusha SharifinejadAtossa MadanipourMaria Marluce Dos Santos VilelaEdyta Heropolitańska-PliszkaGholamreza Azizi

Published in: Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology (2023)

Our results showed that apart from undiagnosed IgAD patients, IgAD patients represent a wide range of clinical manifestations. Infection, allergy, and autoimmunity are the most common clinical manifestations. The concurrent presence of IgA and IgG subtypes deficiency could be associated with increased susceptibility to infection. Considering the probability of developing new clinical complications during follow-up, periodic assessments of IgAD patients should be inspected.

Keyphrases

ejection fraction
newly diagnosed
prognostic factors
squamous cell carcinoma
radiation therapy
risk factors
replacement therapy
smoking cessation