Single-cell deconvolution algorithms analysis unveils autocrine IL11-mediated resistance to docetaxel in prostate cancer via activation of the JAK1/STAT4 pathway.

Bisheng ChengLingfeng LiTianlong LuoQiong WangYong LuoShoumin BaiKaiwen LiYiming LaiHai Huang

Published in: Journal of experimental & clinical cancer research : CR (2024)

Our findings identify an autocrine loop of IL-11/IL-11RA that confers docetaxel resistance through the JAK1/STAT4 pathway. The pSTAT4-CBP interaction serves as a critical enhancer of c-MYC transcriptional activity in prostate cancer cells. Targeting this signalling axis presents a potential therapeutic strategy to overcome docetaxel resistance in advanced prostate cancer.

Keyphrases

prostate cancer
radical prostatectomy
single cell
transcription factor
locally advanced
machine learning
rheumatoid arthritis
gene expression
squamous cell carcinoma
high throughput
rna seq
radiation therapy
cancer therapy
systemic lupus erythematosus
ankylosing spondylitis
heat stress