Nucleophilic strategies to construct -CF 2 - linkages using borazine-CF 2 Ar reagents.

Michael M Wade WolfeShuo GuoLucy S YuTrenton R VogelJoseph W TuckerNathaniel K Szymczak

Published in: Chemical communications (Cambridge, England) (2022)

Using a Lewis acid-quenched CF 2 Ph - reagent, we show C-C bond formation through nucleophilic addition reactions to prepare molecules containing internal -CF 2 - linkages. We demonstrate C(sp 2 )-C(sp 3 ) coupling using both S N Ar reactions and Pd-catalysis. Finally, C(sp 3 )-C(sp 3 ) bonds are forged using operationally simple S N 2 reactions that tolerate medicinally-relevant motifs.

Keyphrases

cystic fibrosis
electron transfer