Nucleophilic strategies to construct -CF 2 - linkages using borazine-CF 2 Ar reagents.
Michael M Wade WolfeShuo GuoLucy S YuTrenton R VogelJoseph W TuckerNathaniel K SzymczakPublished in: Chemical communications (Cambridge, England) (2022)
Using a Lewis acid-quenched CF 2 Ph - reagent, we show C-C bond formation through nucleophilic addition reactions to prepare molecules containing internal -CF 2 - linkages. We demonstrate C(sp 2 )-C(sp 3 ) coupling using both S N Ar reactions and Pd-catalysis. Finally, C(sp 3 )-C(sp 3 ) bonds are forged using operationally simple S N 2 reactions that tolerate medicinally-relevant motifs.
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