Tri-methylation of ATF7IP by G9a/GLP recruits the chromodomain protein MPP8.

Takeshi TsusakaMasaki KikuchiTadahiro ShimazuTakehiro SuzukiYoshihiro SohtomeMai AkakabeMikiko SodeokaNaoshi DohmaeTakashi UmeharaYoichi Shinkai

Published in: Epigenetics & chromatin (2018)

Our findings provide new insights into the roles of lysine methylation in non-histone substrates which are targeted by the G9a/GLP complex and suggest a potential function of ATF7IP methylation in SETDB1/MPP8-mediated transgene silencing.

Keyphrases

dna methylation
genome wide
transcription factor
endoplasmic reticulum stress
cancer therapy
small molecule
risk assessment
human health
climate change