Genetically Determined Reproductive Aging and Coronary Heart Disease: A Bidirectional 2-sample Mendelian Randomization.
Veerle DamN Charlotte Onland-MoretStephen BurgessMaria Dolores ChirlaqueSanne A E PetersEwoud SchuitKaja TikkElisabete WeiderpassClare Oliver-WilliamsAngela M WoodAnne TjønnelandChristina C DahmKim OvervadMarie-Christine Boutron-RuaultMatthias B SchulzeAntonia TrichopoulouPietro FerrariGiovanna MasalaVittorio KroghRosario TuminoGiuseppe MatulloSalvatore PanicoJolanda M A BoerW M Monique VerschurenMarit WaasethMaria José Sánchez PérezPilar AmianoLiher ImazConchi Moreno-IribasOlle MelanderSophia HarlidMaria NordendahlPatrik WennbergTimothy J KeyElio RiboliCarmen SantiusteRudolf KaaksVerena A KatzkeClaudia LangenbergNicholas J WarehamHeribert SchunkertJeanette ErdmannChristina WillenborgChristian HengstenbergMarcus Edi KleberGraciela DelgadoWinfried MärzStavroula KanoniGeorge DedoussisPanagiotis DeloukasMajid NikpayRuth McPhersonMarkus ScholzAndrej TerenAdam S ButterworthYvonne T van der SchouwPublished in: The Journal of clinical endocrinology and metabolism (2022)
Genetically determined reproductive aging is not causally associated with CHD risk (factors) in women, nor were the genetic variants associated in men. We found no evidence for a reverse association in a combined sample of women and men.