Levels of Angiopoietin 2 Are Predictive for Mortality in Patients Infected With Yellow Fever Virus.
Cornelia A M van de WegMateus Vailant ThomazellaMariana P MarmoratoCarolina A CorreiaJuliana Z C DiasAlvino MaestriLuiz G F A B E ZanellaNatalia B CerqueiraAlvina C FélixCarlos H V MoreiraRenata BuccheriPriscilla R CostaEsper G KallásPublished in: The Journal of infectious diseases (2024)
In 2018 there was a large yellow fever outbreak in São Paulo, Brazil, with a high fatality rate. Yellow fever virus can cause, among other symptoms, hemorrhage and disseminated intravascular coagulation, indicating a role for endothelial cells in disease pathogenesis. Here, we conducted a case-control study and measured markers related to endothelial damage in plasma and its association with mortality. We found that angiopoietin 2 is strongly associated with a fatal outcome and could serve as a predictive marker for mortality. This could be used to monitor severe cases and provide care to improve disease outcome.
Keyphrases
- endothelial cells
- cardiovascular events
- end stage renal disease
- risk factors
- ejection fraction
- healthcare
- newly diagnosed
- chronic kidney disease
- palliative care
- prognostic factors
- oxidative stress
- early onset
- coronary artery
- physical activity
- quality improvement
- type diabetes
- high glucose
- depressive symptoms
- drug induced