Multimodal MRI of grey matter, white matter, and functional connectivity in cognitively healthy mutation carriers at risk for frontotemporal dementia and Alzheimer's disease.
Rogier A FeisMark J R J BoutsElise G P DopperNicola FilippiniVerena HeiseAaron J TrachtenbergJohn C van SwietenMark A van BuchemJeroen van der GrondClare E MackaySerge A R B RomboutsPublished in: BMC neurology (2019)
Concluding, we could not find differences suggestive of divergent pathways of underlying FTD and AD pathology in asymptomatic risk mutation carriers. Future studies should focus on asymptomatic mutation carriers that are closer to symptom onset to capture the first specific signs that may differentiate between FTD and AD.