Respiratory exacerbations are associated with muscle loss in current and former smokers.
Stefanie Elizabeth MasonRafael Moreta-MartinezWassim W LabakiMatthew StrandDavid BaraghoshiElizabeth A ReganJessica BonRuben San Jose EsteparRichard CasaburiMerry-Lynn N McDonaldHarry RossiterBarry J MakeMark T DransfieldMeiLan K HanKendra A YoungGreg KinneyJohn E HokansonRaul San Jose EsteparGeorge R Washkonull nullnull nullPublished in: Thorax (2021)
Exacerbations are associated with accelerated skeletal muscle loss. Each annual exacerbation was associated with the equivalent of 6 months of age-expected decline in muscle mass. Ameliorating exacerbation-associated muscle loss represents an important therapeutic target.