Naoxintong capsule accelerates mitophagy in cerebral ischemia-reperfusion injury via TP53/PINK1/PRKN pathway based on network pharmacology analysis and experimental validation.
Jinfeng ShangYinlian WenXiaolu ZhangGuijinfeng HuangWenbin ChenBohong WangKai WuQuan XiangXin LiuPublished in: Journal of ethnopharmacology (2024)
This study demonstrates that NXT promotes mitophagy in CIRI through restraining p53 and promoting PINK1/PRKN in vivo and in vitro.