The high methylation level of a novel 151-bp CpG island in the ESR1 gene promoter is associated with a poor breast cancer prognosis.

Laura Itzel Quintas-GranadosHernán CortésManuel González-Del CarmenGerardo Leyva-GómezLilia Patricia Bustamante-MontesMiguel Rodríguez-MoralesEdgar Yebran Villegas-VazquezIsrael López-ReyesSofía Lizeth Alcaraz-EstradaJorge Sandoval-BasilioErnesto Soto-ReyesJavad Sharifi RadGabriela Figueroa-GonzálezOctavio Daniel Reyes-Hernández

Published in: Cancer cell international (2021)

Our findings suggest that methylation at this novel CpG island might be a promising prognosis marker.

Keyphrases

dna methylation
genome wide
copy number
gene expression
transcription factor