Therapy of clinical stage IIA and IIB seminoma: a systematic review.
Julia HeinzelbeckerStefanie SchmidtJulia LacknerJonas BuschCarsten BokemeyerJohannes ClassenAnnette DieingOliver HakenbergSusanne KregeAlexandros PapachristofilouDavid PfisterChristian RufHans SchmelzHeinz SchmidbergerRainer SouchonChristian WinterFriedemann ZengerlingSabine KlieschPeter AlbersChristoph OingPublished in: World journal of urology (2021)
RT and CT are the most commonly applied treatments in CS IIA/B seminoma. In CS IIA seminomas, RRs after RT and CT are similar. However, in CS IIB, CT seems to be more effective. Survival rates of CS IIA/B seminomas are excellent. Consequently, long-term toxicities and SMs are important survivorship issues. Alternative treatment approaches, e.g., retroperitoneal lymph node dissection (RPLND) or dose-reduced sequential CT/RT are currently under prospective investigation.