Simvastatin Effects on Inflammation and Platelet Activation Markers in Hypercholesterolemia.
Cristina BaraleChiara FrascaroliRouslan SenkeevFranco CavalotIsabella RussoPublished in: BioMed research international (2018)
In primary hypercholesterolemia, simvastatin treatment reduced platelet activation and subclinical inflammation and improved endothelial dysfunction. LDL-cholesterol levels were the major correlate of platelet reactivity; however, other effects of statins may contribute to reducing the progression of atherosclerosis.