Paraoxonase single nucleotide variants show associations with polycystic ovary syndrome: a meta-analysis.
Anthicha KunjantarachotPhuntila TharabenjasinHamdi JarjanaziDenise Maria ChristofoliniErik MontagnaCaio Parente BarbosaBianca BiancoPublished in: Reproductive biology and endocrinology : RB&E (2020)
Of the eight PON SNVs examined, two (rs854560 and rs662) were associated with PCOS risk. These 1.4-fold increased risk effects rendered Asians susceptible to PCOS. High statistical power, high significance, zero to low-level heterogeneity, robustness and lack of bias in the core outcomes underpinned the strong evidence for association.