Analysis of Septin 9 Gene Hypermethylation as Follow-Up Biomarker of Colorectal Cancer Patients after Curative Surgery.
Miguel León-ArellanoMariano García-ArranzHéctor GuadalajaraRocío Olivera-SalazarTeresa Valdes-SanchezDamián García-OlmoPublished in: Diagnostics (Basel, Switzerland) (2022)
Detection of methylation of Septin 9 gene in circulating plasma DNA, obtained from a peripheral blood sample, may be a useful, non-invasive and effective method for detecting minimal residual disease and could therefore predict CRC tumor recurrences. The optimal time in our series to obtain the best prediction results based on Septin 9 methylation levels was one month after surgery. Despite these considerable findings, a study with more patients is necessary to obtain more robust conclusions.
Keyphrases
- genome wide
- peripheral blood
- end stage renal disease
- prognostic factors
- dna methylation
- copy number
- ejection fraction
- newly diagnosed
- minimally invasive
- chronic kidney disease
- peritoneal dialysis
- coronary artery bypass
- circulating tumor
- genome wide identification
- rectal cancer
- gene expression
- coronary artery disease
- atrial fibrillation
- real time pcr