Targeting Src SH3 domain-mediated glycolysis of HSC suppresses transcriptome, myofibroblastic activation, and colorectal liver metastasis.

Yuanguo WangXianghu WangBing Bai Aurpita Shaha Xipu HeYingzi HeZhenqing YeVijay H ShahNingling Kang

Published in: Hepatology (Baltimore, Md.) (2024)

The Src SH3 domain-facilitated metabolic reprogramming induced by TGFβ1 represents a target to inhibit CAF activation and the pro-metastatic liver microenvironment.

Keyphrases

tyrosine kinase
stem cells
squamous cell carcinoma
small cell lung cancer
gene expression
signaling pathway
transforming growth factor
single cell
genome wide
anti inflammatory
epithelial mesenchymal transition