Intravenous Amiodarone and Sotalol Impair Contractility and Cardiac Output, but Procainamide Does Not: A Langendorff Study.
Charles MackinElizabeth S DeWittKatherine J BlackXiaoqi TangBrian D PolizzottiSarah J van den BoschMark E AlexanderJohn J KheirPublished in: Journal of cardiovascular pharmacology and therapeutics (2018)
In isolated hearts, amiodarone and sotalol depressed myocardial contractility, cardiac output, and diastolic function. However, procainamide did not negatively affect myocardial performance and represents a favorable agent in settings of therapeutic equivalence.