Linezolid@MOF-74 as a host-guest system with antimicrobial activity.
Dalia RamosJavier Aguila-RosasCarlos T Quirino-BarredaAlfonso Santiago-TellezHugo A Lara-GarcíaAriel GuzmánIlich A IbarraEnrique LimaPublished in: Journal of materials chemistry. B (2022)
Linezolid (LNZ) is a new-generation synthetic molecule for the antibacterial treatment of severe infections, particularly in infective cases where the bacterial resistance to first-choice drugs is caused by Gram-positive pathogens. In this context, since 2009, some strains resistant to LNZ in patients with long-term treatments have been reported. Therefore, there is a need to use not only new drug molecules with antibacterial activities in the dosage form but also a different approach to pharmacotherapeutic strategies for skin infections, which lead to a reduction in the concentration of biocides. This work explores LNZ hosted at two isostructural MOFs, MOF-74(Zn) and MOF-74(Cu), as promising antimicrobial systems for gradual biocide release within 6 h. These systems reach a lower minimum inhibitory concentration (MIC) in comparison to free LNZ. Even a decreased MIC value is also observed, which is an encouraging result regarding the efficiency of the systems to control concentration-dependent antimicrobial resistance.
Keyphrases
- antimicrobial resistance
- metal organic framework
- gram negative
- escherichia coli
- methicillin resistant staphylococcus aureus
- wound healing
- silver nanoparticles
- staphylococcus aureus
- drug induced
- heavy metals
- early onset
- emergency department
- soft tissue
- combination therapy
- decision making
- adverse drug
- replacement therapy
- electronic health record
- risk assessment
- smoking cessation
- water soluble
- clinical evaluation