HIF-1α stimulates the progression of oesophageal squamous cell carcinoma by activating the Wnt/β-catenin signalling pathway.

Kang Tang Takeshi ToyozumiKentaro MurakamiHaruhito SakataMasayuki KanoSatoshi EndoYasunori MatsumotoHiroshi SuitoMasahiko TakahashiNobufumi SekinoRyota OtsukaKazuya KinoshitaSoichiro HirasawaJie HuMasaya UesatoKoichi HayanoHisahiro Matsubara

Published in: British journal of cancer (2022)

HIF-1α serves as an oncogenic transcriptional factor in ESCC, probably by directly targeting TCF4/TCF7L2 and activating the Wnt/β-catenin pathway.

Keyphrases

cell proliferation
squamous cell carcinoma
signaling pathway
stem cells
transcription factor
endothelial cells
epithelial mesenchymal transition
gene expression
cancer therapy
lymph node metastasis
oxidative stress
radiation therapy