Gut permeability is affected by sex and increased in children with irritable bowel syndrome but not in functional abdominal pain.
Robert J ShulmanSridevi DevarajMargaret HeitkemperPublished in: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society (2019)
Sex is a critically important factor when measuring gut permeability. Boys with IBS have increased lactulose/mannitol ratios and percent sucralose recovery. Girls with IBS have increased percent recovery of sucrose. Children with FAP do not demonstrate abnormal gut 0permeability even taking sex into account.