cfDNA and DNases: New Biomarkers of Sepsis in Preterm Neonates-A Pilot Study.

Moritz LenzThomas MaibergerLina ArmbrustAntonia KiwitAxel Von der WenseKonrad ReinshagenJulia ElrodMichael Boettcher

Published in: Cells (2022)

A total of 31 preterm neonates with suspected sepsis were included. Out of these, nine patients met the criteria for sepsis according to EMA. Regarding early onset neonatal sepsis (3 EONS vs. 10 controls), cfDNA, DNase I, nucleosome, and CRP were elevated significantly. H3Cit and NE did not show any significant elevations. In the late onset sepsis collective (6 LONS vs. 12 controls), cfDNA, DNase I, and CRP differed significantly compared to control group.

Keyphrases

early onset
late onset
septic shock
acute kidney injury
intensive care unit
low birth weight
preterm birth
end stage renal disease
newly diagnosed
ejection fraction
preterm infants
pulmonary embolism
tyrosine kinase
patient reported outcomes