A novel antiviral lncRNA, EDAL, shields a T309 O-GlcNAcylation site to promote EZH2 lysosomal degradation.
Baokun SuiDong ChenWei LiuQiong WuBin TianYingying LiJing HouShiyong LiuJuan XieHao JiangZhaochen LuoLei LvFei HuangRuiming LiChengguang ZhangYuling TianMin CuiMing ZhouHuanchun ChenZhen F FuYi ZhangLing ZhaoPublished in: Genome biology (2020)
Our findings show that a neuronal lncRNA can exert an effective antiviral function via blocking a specific O-GlcNAcylation that determines EZH2 lysosomal degradation, rather than the traditional interferon-dependent pathway.