Do Alarmins Have a Role in Multiple Myeloma?
Alper GedükMerve Gokcen PolatEsra Terzi DemirsoyBerrin ÖztaşBaldan Huri EryılmazEmel Merve YenihayatHayrunnisa AlbayrakHasim Atakan ErolÖzgür MehtaPınar TarkunAbdullah HacıhanefioğluPublished in: Turkish journal of haematology : official journal of Turkish Society of Haematology (2024)
In this study, we found that serum CLP, S100A6, and HMGN1 levels were statistically lower in patients with newly diagnosed MM compared to the control group. These results suggest that CLP may bind to the paraprotein produced by heavy chain MM in the blood, causing its blood levels to be low. Additionally, low levels of HMGN1, which is involved in DNA repair, suggest that HMGN1 may contribute to the complex genetic abnormalities found in cases of MM.