Association of immune-related adverse events with the outcomes of immune checkpoint inhibitors in patients with dMMR/MSI-H metastatic colorectal cancer.
Vincenzo NascaFrancesco BarrettaFrancesca CortiSara LonardiMonica NigerMaria Elena ElezMarwan FakihPriya JayachandranAakash Tushar ShahMassimiliano SalatiElisabetta FenocchioLisa SalvatoreChiara CremoliniJavier RosMargherita AmbrosiniGiacomo MazzoliRossana IntiniMichael J OvermanRosalba MiceliFilippo PietrantonioPublished in: Journal for immunotherapy of cancer (2023)
Our results demonstrate that not all irAEs could exert a protective effect on oncologic outcome. An easy-to-use model for ICIs toxicity (burden score of protective and harmful irAEs) may be used as surrogate marker of response.