Urinary levels of ceruloplasmin and monocyte chemoattractant protein-1 correlate with extra-capillary proliferation and chronic damage in patients with lupus nephritis.
Tomás Urrego-CallejasSimón Sandoval ÁlvarezLuis F AriasBlanca Ortiz ReyesAdriana L Vanegas-GarcíaLuis A GonzálezCarlos H Muñoz-VahosGloria VásquezLuis F QuintanaJosé A Gómez-PuertaPublished in: Clinical rheumatology (2020)
In SLE patients, serum anti C1q antibodies and urinary CP were associated with activity on kidney biopsy and MCP-1 with chronic damage. This panel of biomarkers could be validated in larger, multi-ethnic population as a complementary tool for better stratification of LN patients. Key Points • Urinary biomarkers are complementary useful tools for the assessment of SLE patients. • Urinary levels of CP correlated with activity findings on kidney biopsy in LN patients. • Urinary levels of MCP-1 correlated with chronic damage, especially with fibrous crescents, tubular atrophy, and interstitial fibrosis.