Next-Generation Sequencing to Detect Pathogens in Pediatric Febrile Neutropenia: A Single-Center Retrospective Study of 112 Cases.

Kazuhiro HoribaYuka ToriiToshihiko OkumuraSuguru TakeuchiTakako SuzukiJun-Ichi KawadaHideki MuramatsuYoshiyuki TakahashiTomoo OgiYoshinori Ito

Published in: Open forum infectious diseases (2021)

NGS technique has great potential for detecting causative pathogens in patients with FN. Cluster analysis, which extracts characteristic microorganisms from a complex microbial population, may be effective to detect pathogens in minute quantities of microbiota, such as those from the bloodstream.

Keyphrases

gram negative
multidrug resistant
antimicrobial resistance
microbial community
chemotherapy induced
copy number
risk assessment
climate change
circulating tumor
genome wide