Higher sensitivity of female cells to ethanol: methylation of DNA lowers Cyp2e1, generating more ROS.

Carlos G PenalozaMayra CruzGabrielle GermainSidra JabeenMohammad JavdanRichard A LockshinZahra Zakeri

Published in: Cell communication and signaling : CCS (2020)

We conclude that the sex-differential cell death caused by ethanol derives from sex dimorphic methylation of Cyp2e1 gene, resulting in generation of more ROS.

Keyphrases

cell death
cell cycle arrest
genome wide
dna methylation
induced apoptosis
dna damage
reactive oxygen species
circulating tumor
copy number
cell free
endoplasmic reticulum stress
gene expression
oxidative stress
signaling pathway
genome wide identification
cell proliferation
nucleic acid
circulating tumor cells