Adolescent female rats recovered from the activity-based anorexia display blunted hedonic responding.
Matthew M HurleyAshraf N NawariVictoria X ChenShannon C O'BrienAliasgher I SabirEthan J GoodmanLucas J WilesAditi BiswasSean Andrew AstonSeva G KhambadkoneKellie L TamashiroTimothy H MoranPublished in: The International journal of eating disorders (2022)
Patients recovered from anorexia nervosa report anhedonia, or the lack of pleasure in consuming palatable foods. Unfortunately, the biological mechanism underpinning anhedonia in anorexia nervosa is not well understood. The current study assessed hedonic state in adolescent female rats prior to and 10 days recovered following the activity-based anorexia paradigm. Age-matched, running wheel-matched and body weight-matched control groups were also tested at the same time points.